GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs5752326 | 1 | rs5752326 | chr22:26843990 | HPS4 | chr22:26847447-26879820:- | 0.3 | 3.76 | 0.000195 | Ischemic stroke |
| THCA | cis | rs5752326 | 1 | rs5752327 | chr22:26844070 | HPS4 | chr22:26847447-26879820:- | 0.3 | 3.75 | 0.000201 | Ischemic stroke |
| THCA | cis | rs4141404 | 1 | rs5753521 | chr22:31638027 | RNF185 | chr22:31556138-31603004:+ | -0.27 | -4.98 | 8.82E-7 | Paclitaxel-induced neuropathy |
| THCA | cis | rs7951870 | 1 | rs57535407 | chr11:46570286 | PACSIN3 | chr11:47199085-47207958:- | 0.18 | 4.13 | 4.29E-5 | Schizophrenia |
| THCA | cis | rs4141404 | 1 | rs5753543 | chr22:31685458 | RNF185 | chr22:31556138-31603004:+ | -0.28 | -5.22 | 2.7E-7 | Paclitaxel-induced neuropathy |
| THCA | cis | rs60843830 | 1 | rs57542652 | chr2:228088 | SH3YL1 | chr2:218138-264810:- | -0.94 | -24.47 | 2.41E-86 | Spherical equivalent (joint main effects and education interaction) |
| THCA | cis | rs5756813 | 1 | rs5756813 | chr22:38175477 | LGALS2 | chr22:37966254-37976024:- | 0.16 | 4.48 | 9.16E-6 | Optic cup area;Vertical cup-disc ratio |
| THCA | cis | rs5756813 | 1 | rs5756813 | chr22:38175477 | TRIOBP | chr22:38082344-38172562:+ | -0.38 | -10.78 | 2.04E-24 | Optic cup area;Vertical cup-disc ratio |
| THCA | cis | rs2076028 | 1 | rs5757141 | chr22:38957483 | JOSD1 | chr22:39081549-39096459:- | -0.15 | -3.95 | 8.9E-5 | Resting heart rate |
| THCA | cis | rs2076028 | 1 | rs5757141 | chr22:38957483 | TOMM22 | chr22:39077954-39080763:+ | -0.19 | -4.19 | 3.35E-5 | Resting heart rate |
| THCA | cis | rs2076028 | 1 | rs5757162 | chr22:38993370 | JOSD1 | chr22:39081549-39096459:- | -0.14 | -3.67 | 0.000268 | Resting heart rate |
| THCA | cis | rs2076028 | 1 | rs5757162 | chr22:38993370 | LOC646851 | chr22:38974125-39052634:- | 0.13 | 3.59 | 0.000369 | Resting heart rate |
| THCA | cis | rs2076028 | 1 | rs5757162 | chr22:38993370 | TOMM22 | chr22:39077954-39080763:+ | -0.16 | -3.5 | 0.000516 | Resting heart rate |
| THCA | cis | rs2076028 | 1 | rs5757166 | chr22:38995385 | LOC646851 | chr22:38974125-39052634:- | 0.14 | 3.86 | 0.000131 | Resting heart rate |
| THCA | cis | rs2076028 | 1 | rs5757166 | chr22:38995385 | TOMM22 | chr22:39077954-39080763:+ | -0.16 | -3.52 | 0.000471 | Resting heart rate |